Matt and Kevin take a humbling look back a classic 1989 immunology paper
from the lab of David Baltimore (RIP)
in which the gene encoding RAG-1,
one of two genes that is responsible for
the VDJ recombination -
a mechanism for the generation of diversity
in the adaptive immune system.
Matt and Kevin discuss a new paper about the "subfornical organ"
which (once again) undermines the idea of immune privilage,
and also points to an interesting evolutionary question:
why would T-cells migrating from fat to the brain affect hunger response?
I'm certain that what you've really been missing in these dark times
is two guys mansplaining menstruation...but also cool immunology!
