I swear, we know how to count; this episode was originally recorded back in January, but Camilla's audio file was weirdly corrupted. And in this attempt, Chadene's computer exploded, but we soldiered on without her.
In this episode, Chadene, Kate and Kevin discuss Kate's recently published paper about how STING, once thought to be involved only in defense against DNA viruses, actually slows RNA virus replication as well. Also, Chadene throws herself under the bus, and Kevin manages to only talk for about 20% of the time.
In this episode, we're talking about *Salmonella*, and the peculiar way in which it tries to keep you eating to keep you alive. Who knew pathogens could be so kind?
In this episode, Kevin and Camilla discuss *Salmonella* virulence,* and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job.
Today (well, three weeks ago), Matt and Kevin talked about epitope spreading in Lupus, and a ton of crazy mouse models that allowed researchers to dissect the way a single auto-reactive B-cell clone can spread the disease party to its neighbors.
In this episode, we're talking cure for the common cold... or at least, a vaccine for it. Also, Kevin and Matt read the wrong paper, Chadene corrects Kevin's pronunciation of her name (again!) and we give a big round of applause for Dr. Kate Franz (though she's still too busy for us).
In this episode, we're talking cancer, checkpoint blockade and poop - what's not to love? Also, Camilla is the only one drinking, Matt thinks the study needs more mice, and it took Kevin an extra 2 hours to edit this episode to remove all (he hopes) of his sniffles.
We've got a couple of new hosts - Please give a warm welcome to Chadene Tremaglio and Camilla Engblom! Kate is still holed up in a cave (lab) trying to wrap up her PhD. But she'll soon return... we hope...
Audiommunity loves Tasmanian devils, so we bite the shit out of them... In this episode, we're talking about a contagious tumor that couldn't happen to a nicer species. No seriously, it really couldn't. Tasmanian devils bite each other on the face to say hello. WTF devils?
This week - Evidence that viruses drive the evolution of their hosts - who would have guessed? Matt struggles to remember how evolution works, and Kate and Kevin yell past each other about open peer review.
In this episode, Matt and Kevin give in to aesthetics. This paper's just really pretty.
This week, a guy gets a kiwi allergy from a bone marrow transplant from his sister, Matt envisions a magic mouse, and Kate peaces out after 20 min. Meanwhile, Kevin continues to be the only one drinking... that schtick may not last much longer.
Something a bit different this episiode. Last month, we joined Jesse Noar, host of the excellent Bacteriophiles podcast to record an episode about oncolytic viruses (viruses that blow up cancer cells).
In this episode, how parasitic worms alter in immunomodulatory effects of the gut microbiome. Also, Kate expresses her distaste for large datasets and animal experiments, and Matt proposes a weight loss company that will only market to identical twins.
In this episode, we talk about the innate immune system's Trojan cow strategy - using a cyclic dinucleotide as a signaling molecule means that viruses can package the seeds of their own destruction.
In this episode we talk about lymphatics in the brain and why that's both obvious and not obvious. Meanwhile, Kate drinks disgusting smoothies and Kevin triggers Matt with a trigger warning.
In this episode, Matt and Kevin discuss checkpoint blockade cancer immunotherapy (wow, that's a mouthful). When cancer stamps down the breaks of the immune system, cutting the break line can allow T-cells to do their job.
This week, we're discussing DRACOs - not the Harry Potter character, a "new" class of antiviral therapeutics that links up the double-stranded RNA-binding part of one protein to the cell-death (apoPtosis)-activating part of a different protein.
In this episode, we're talking about the placental microbiome - that is, the bacteria that hang around a developing fetus in the womb. Wait, there are bacteria hanging around a developing fetus? Apparently!
In this episode, we discuss the moral implications of doing experiments on babies without brains, and editing the genomes of unborn humans. I reveal my nature as a moral monster, and Kate can't resist bringing up Kim Kardashian's artificial selection of her own offspring.
To celebrate the return of the warm(ish) weather, we discuss a paper looking at immune responses to bee venom, and the underlying causes of environmental allergy.
A discussion about sCD38, a molecule that's secreted in mouse and human sperm,
and may play a role in suppressing a mother's immune response to a new fetus.
Turns out *Staphylococcus aureus* can evade the immune system by activating it.
Also, Matt's bad hair day and a link between tacos and tampons.
In this episode, we're joined by Abbie Smith, a postdoctoral fellow studying HIV at Emory University, and author of the popular (and always wonderful) ERV blog.
Kate and Kevin talk influenza and gain of function research. Should we be making flu more deadly?
After a hard day's work, sometimes you want to just kick your feet back and relax. Unfortunately, sometimes your CD8 T-cells want the same thing, even though they don't have feet.
In this episode, Kevin talks with Pamela Ronald, professor of plant pathology at the University of California, Davis. Almost 20 years ago, Ronald discovered Xa21, a plant pattern recognition receptor that guards against bacterial infection. This receptor shares many features with Toll-like receptors, and the role of Xa21 was shown a year before TLRs were implicated in immunity.
In Episode 5, we're talking about neutrophils, and the special way they die.
After a long absence, we're back! With an episode about the autoimmune disease multiple sclerosis and how immune cells navigate the around the body.
Today, we're talking the *other* immunity (that both Kate and Kevin happen to study). Neglected for nearly one hundred years, the innate immune system is required for getting inflammation going, and without it, adaptive immunity wouldn't function.
In this episode, we're talking antibodies - what they are and what they have to do with Vaccines. Also, we discuss efforts to use engineered antibodies to treat HIV.
In this episode, we're talking transplantation: Why is it so damned hard to transfer tumors between mice? Why do we have to go to extraordinary lengths to transplant kidneys between humans?
